You have less energy, increased fatigue, or difficulty focusing. Toxins and other pollutants may accumulate in the blood as a result of severe renal impairment. People may experience fatigue, a feeling of weakness, and difficulty concentrating as a result. Anaemia, which can result in weariness and weakness, is another side effect of kidney illness. You are having problems falling asleep. Toxins do not exit the body through the urine when the kidneys are not filtering the blood adequately. This may make it challenging to fall asleep. Additionally, there is a connection between obesity and chronic kidney disease, and those with chronic kidney disease have a higher prevalence of sleep apnea than people without the condition. Your skin is scratchy and dry. When the kidneys are unable to maintain the proper balance of minerals and nutrients in your blood, severe renal disease can frequently be accompanied by mineral and bone illness, which can manifest as dry and itchy skin. You experience a greater urge to urinate. The need to urinate more frequently, especially at night, may indicate renal disease. An increased urge to urinate may result from damage to the kidney filters. This may occasionally also indicate a urinary infection or an enlarged prostate in males. Your pee contains visible blood. When filtering wastes from the blood to make urine, healthy kidneys normally keep the blood cells in the body.