When people became more aware of their surroundings, the history of herbs and other plants being used for medical purposes began to fade. Most medicinal plants have been documented as medicine in the past. According to a World Health Organization (WHO) research, 80 percent of people in underdeveloped nations rely on traditional medicine for their primary health care, with plant extracts accounting for 85 percent of those medicines. As a result of the cultural acceptability of doctors and local pharmacopeias, the affordability of traditional medicine, and poor access to modern health facilities, up to 80% of the population in Ethiopia uses traditional medicine. Natural compounds derived from aromatic plants are one of the promising sources for antibacterial, antioxidant, and free radical scavenging agents screening. One of the most well-known and extensively used home medicines is Ocimum Lamiifolium (Damakese). To extract the essential oil from the shade dried leaves of Ocimum Lamiifolium, hydrodistillation in a Clevenger-type equipment was used. Antibiotic resistance is rising among microorganisms such as bacteria, viruses, and fungi, and there is a lack of medications often used to treat infectious diseases, which is becoming a serious worldwide health issue. This piqued the researchers’ interest, prompting them to look for alternative natural products with a wide range of biological activity. Natural ingredients are becoming more valuable sources of novel drugs these days. Natural compounds and derivatives still account for more than half of all medications in clinical trials. Plants, fungus, bacteria, insects, and animals have all created natural compounds that have been identified as biologically active pharmacophores. Furthermore, they are well-known in the pharmaceutical business for their great structural diversity and application range.
